Publications

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Sharp NP, Sandell L, James CG, Otto SP. (2018) The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast. Proceedings of the National Academy of Sciences USA 115: E5046-5055. Link

Sharp NP, Otto SP. (2018) Zeroing in on the rate of genome doubling. Current Biology 28: R306-R327. Link

Sharp NP, Agrawal AF. (2018) An experimental test of the mutation-selection balance model for the maintenance of genetic variance in fitness components. Proceedings of the Royal Society B 285: 20181864. Link

Gilbert KJ, Sharp NP, Angert AL, Conte GL, Draghi JA, Guillaume F, Hargreaves AL, Matthey-Doret R, Whitlock MC. (2017) Local adaptation interacts with expansion load during range expansion: Maladaptation reduces expansion load. American Naturalist 189: 368-380. Link

Sharp NP, Otto SP (2016) Evolution of sex: Using experimental genomics to select among competing theories. BioEssays 38: 751-757. Link

Sharp NP, Agrawal AF (2016) Low genetic quality affects key dimensions of the mutational spectrum. PLoS Biology 14: e1002419. Link

Sharp NP, Agrawal AF (2016) The decline in fitness with inbreeding: evidence for negative dominance-by-dominance epistasis in Drosophila melanogaster. Journal of Evolutionary Biology 29: 857-864. Link

Sharp NP, Vincent CM (2015) The effect of parasites on sex differences in selection. Heredity 114: 367-372. Link

Vincent CM, Sharp NP (2014) Sexual antagonism for resistance and tolerance to infection in Drosophila melanogaster. Proceedings of the Royal Society B. 281: 20140987. Link

Wang AD, Sharp NP, Agrawal AF (2014) Sensitivity of mutational fitness effects to environment, genetic background, and adaptedness: a case study with Drosophila. Evolution 68: 840-853. Link

Sharp NP, Agrawal AF (2013) Male-biased fitness effects of spontaneous mutations in Drosophila melanogaster. Evolution 67: 1189-1195. Link

Clark SCA, Sharp NP, Rowe L, Agrawal AF (2012) Relative effectiveness of mating success and sperm competition offence at eliminating deleterious mutations in Drosophila melanogaster. PLoS ONE 7: e37351. Link

Sharp NP, Agrawal AF (2012) Evidence for elevated mutation rates in low-quality genotypes. Proceedings of the National Academy of Sciences USA 109:6142-6146. Link

Wang AD, Sharp NP, Spencer CC, Tedman-Aucoin K, Agrawal AF (2009) Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster. American Naturalist 174: 863-874. Link

Sharp NP, Agrawal AF (2009) Sexual selection and the random union of gametes: Testing for a correlation in fitness between mates in Drosophila melanogaster. American Naturalist 174:613-622. Link

Sharp NP, Agrawal AF (2008) Mating density and the strength of sexual selection against deleterious alleles in Drosophila melanogaster. Evolution 62:857-867. Link