Publications

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Sandell L, Sharp NP (2022) Fitness effects of mutations: An assessment of PROVEAN predictions using mutation accumulation data. Genome Biology and Evolution 14. Link

Gerstein AC, Sharp NP (2021) The population genetics of ploidy change in unicellular fungi. FEMS Microbiology Reviews 45:fuab006. Link

Sharp NP, Whitlock MC. (2019) No evidence of positive assortative mating for genetic quality in fruit flies. Proceedings of the Royal Society B 286: 20191474. Link

Sharp NP, Sandell L, James CG, Otto SP. (2018) The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast. Proceedings of the National Academy of Sciences USA 115: E5046-5055. Link

Sharp NP, Otto SP. (2018) Zeroing in on the rate of genome doubling. Current Biology 28: R306-R327. Link

Sharp NP, Agrawal AF. (2018) An experimental test of the mutation-selection balance model for the maintenance of genetic variance in fitness components. Proceedings of the Royal Society B 285: 20181864. Link

Gilbert KJ, Sharp NP, Angert AL, Conte GL, Draghi JA, Guillaume F, Hargreaves AL, Matthey-Doret R, Whitlock MC. (2017) Local adaptation interacts with expansion load during range expansion: Maladaptation reduces expansion load. American Naturalist 189: 368-380. Link

Sharp NP, Otto SP (2016) Evolution of sex: Using experimental genomics to select among competing theories. BioEssays 38: 751-757. Link

Sharp NP, Agrawal AF (2016) Low genetic quality affects key dimensions of the mutational spectrum. PLoS Biology 14: e1002419. Link

Sharp NP, Agrawal AF (2016) The decline in fitness with inbreeding: evidence for negative dominance-by-dominance epistasis in Drosophila melanogaster. Journal of Evolutionary Biology 29: 857-864. Link

Sharp NP, Vincent CM (2015) The effect of parasites on sex differences in selection. Heredity 114: 367-372. Link

Vincent CM, Sharp NP (2014) Sexual antagonism for resistance and tolerance to infection in Drosophila melanogaster. Proceedings of the Royal Society B. 281: 20140987. Link

Wang AD, Sharp NP, Agrawal AF (2014) Sensitivity of mutational fitness effects to environment, genetic background, and adaptedness: a case study with Drosophila. Evolution 68: 840-853. Link

Sharp NP, Agrawal AF (2013) Male-biased fitness effects of spontaneous mutations in Drosophila melanogaster. Evolution 67: 1189-1195. Link

Clark SCA, Sharp NP, Rowe L, Agrawal AF (2012) Relative effectiveness of mating success and sperm competition offence at eliminating deleterious mutations in Drosophila melanogaster. PLoS ONE 7: e37351. Link

Sharp NP, Agrawal AF (2012) Evidence for elevated mutation rates in low-quality genotypes. Proceedings of the National Academy of Sciences USA 109:6142-6146. Link

Wang AD, Sharp NP, Spencer CC, Tedman-Aucoin K, Agrawal AF (2009) Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster. American Naturalist 174: 863-874. Link

Sharp NP, Agrawal AF (2009) Sexual selection and the random union of gametes: Testing for a correlation in fitness between mates in Drosophila melanogaster. American Naturalist 174:613-622. Link

Sharp NP, Agrawal AF (2008) Mating density and the strength of sexual selection against deleterious alleles in Drosophila melanogaster. Evolution 62:857-867. Link